Recurrent hypersomnia: Report of medication-responsive cases
نویسندگان
چکیده
INTRODUCTION Recurrent hypersomnia (RH) is a rare disorder without established treatment. METHODS We report 2 RH medication-responsive cases with typical characteristics of Kleine-Levin syndrome (KLS). CASE-REPORTS A 10 y.o. girl and a 14 y.o. boy presented with sudden sleepiness for 3-9 days (every 2-3 weeks). Physical examination, brain images and blood tests were normal. Polysomnographic findings were heterogenous, including disrupted sleep architecture. MSLTs revealed 2-3 SOREMPs and short sleep latency. Carbamazepine rendered girl׳s sleep normalization, while risperidone normalized boy׳s sleep cycles. CONCLUSIONS Facing the absence of clinical trials in RH, reports of responsive cases are the available therapeutic evidence.
منابع مشابه
Recurrent hypersomnia: a review of 339 cases.
Based on 339 cases this review identifies, quantifies and compares 4 clinical forms of recurrent hypersomnia (1) Kleine-Levin syndrome (KLS) (239 cases), (2) Kleine-Levin syndrome without compulsive eating (KLS WOCE) (54 cases), (3) Menstrual related hypersomnia (MRH) (18 cases) and Recurrent hypersomnia with comorbidity (RHC) (28 cases). A second part of the review considers the main current i...
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